Sofinnova Investments 13F annual report

Sofinnova Investments is an investment fund managing more than $1.59 trillion ran by Nathalie Auber. There are currently 72 companies in Mrs. Auber’s portfolio. The largest investments include Natera Inc and Vera Therapeutics Inc, together worth $269 billion.

Limited to 30 biggest holdings

$1.59 trillion Assets Under Management (AUM)

As of 8th August 2024, Sofinnova Investments’s top holding is 1,550,280 shares of Natera Inc currently worth over $168 billion and making up 10.6% of the portfolio value. Relative to the number of outstanding shares of Natera Inc, Sofinnova Investments owns more than approximately 0.1% of the company. In addition, the fund holds 2,793,987 shares of Vera Therapeutics Inc worth $101 billion. The third-largest holding is Ascendis Pharma A/S worth $100 billion and the next is Novo-nordisk A S worth $92.7 billion, with 649,541 shares owned.

Currently, Sofinnova Investments's portfolio is worth at least $1.59 trillion. The total portfolio value may be much higher due to cash assets that are not publicly disclosed such as fixed income, real estate, or cash equivalents.

Careers at Sofinnova Investments

The Sofinnova Investments office and employees reside in Menlo Park, California. According to the last 13-F report filed with the SEC, Nathalie Auber serves as the Attorney-in-Fact at Sofinnova Investments.

Recent trades

In the most recent 13F filing, Sofinnova Investments revealed that it had opened a new position in Edwards Lifesciences Corp and bought 724,225 shares worth $66.9 billion. This means they effectively own approximately 0.1% of the company. Edwards Lifesciences Corp makes up 5.6% of the fund's Health Care sector allocation and has decreased its share price by 16.7% in the past year.

The investment fund also strengthened its position in Novo-nordisk A S by buying 37,657 additional shares. This makes their stake in Novo-nordisk A S total 649,541 shares worth $92.7 billion.

On the other hand, there are companies that Sofinnova Investments is getting rid of from its portfolio. Sofinnova Investments closed its position in Merck & Co Inc on 15th August 2024. It sold the previously owned 651,299 shares for $85.9 billion. Nathalie Auber also disclosed a decreased stake in Ascendis Pharma A/S by approximately 0.1%. This leaves the value of the investment at $100 billion and 734,284 shares.

One of the largest hedge funds

The two most similar investment funds to Sofinnova Investments are Sageworth Trust Co and Empire Life Investments. They manage $1.59 trillion and $1.59 trillion respectively.


Nathalie Auber investment strategy

Sofinnova Investments’s portfolio is diversified across 3 sectors. Currently, their heaviest sector is Health Care — making up 75.1% of the total portfolio value. The fund focuses on investments in the United States as 62.5% of the portfolio companies are based in the United States.

The majority of the companies in the fund’s portfolio are large-cap stocks. Stocks with a size of more than $10 billion in market cap make up 21% of the total holdings value. On the other hand, small-cap stocks make up only 8.3% of the portfolio. The average market cap of the portfolio companies is close to $15.3 billion.

The complete list of Sofinnova Investments trades based on 13F SEC filings

These positions were updated on August 15th based on the fund’s latest 13F filing. Quickly find out what the most recently closed or increased positions are.

Security Shares Owned Value Allocation
Natera Inc
No change
1,550,280
$167,879,821,000 10.58%
Vera Therapeutics Inc
No change
2,793,987
$101,086,450,000 6.37%
Ascendis Pharma A/S
2.62%
734,284
$100,141,652,000 6.31%
Novo-nordisk A S
6.15%
649,541
$92,715,482,000 5.84%
Merck & Co Inc
Closed
651,299
$85,938,903,000
Incyte Corp.
Closed
1,327,178
$75,609,331,000
Edwards Lifesciences Corp
Opened
724,225
$66,896,663,000 4.22%
Stryker Corp.
Opened
193,084
$65,696,831,000 4.14%
Astrazeneca plc
34.31%
801,417
$62,502,512,000 3.94%
Argenx Se
Closed
149,300
$58,782,396,000
Dyne Therapeutics, Inc.
16.06%
1,625,703
$57,371,059,000 3.62%
Align Technology, Inc.
128.87%
218,524
$52,758,249,000 3.32%
Inhibrx, Inc.
Closed
1,302,645
$45,540,469,000
Rapport Therapeutics Inc
Opened
1,951,562
$45,393,332,000 2.86%
Syndax Pharmaceuticals Inc
33.89%
2,153,669
$44,214,825,000 2.79%
Elanco Animal Health Inc
12.08%
2,864,250
$41,331,128,000 2.60%
IDEAYA Biosciences, Inc.
47.33%
1,151,528
$40,430,148,000 2.55%
Intuitive Surgical Inc
38.09%
87,217
$38,798,482,000 2.44%
Alnylam Pharmaceuticals Inc
43.57%
147,929
$35,946,747,000 2.27%
TG Therapeutics Inc
6.23%
1,861,277
$33,112,118,000 2.09%
Arrivent Biopharma Inc
No change
1,696,752
$31,474,750,000 1.98%
Idexx Labs Inc
15.10%
63,862
$31,113,566,000 1.96%
Sarepta Therapeutics Inc
13.91%
195,852
$30,944,616,000 1.95%
Y-Mabs Therapeutics Inc
No change
2,194,278
$26,506,878,000 1.67%
Axsome Therapeutics Inc
Opened
310,198
$24,970,939,000 1.57%
Cogent Biosciences, Inc.
15.52%
2,773,286
$23,378,801,000 1.47%
Soleno Therapeutics Inc
267.67%
554,359
$22,617,847,000 1.43%
Silk Rd Med Inc
Closed
1,189,024
$21,782,920,000
Savara Inc
128.31%
5,358,918
$21,596,440,000 1.36%
Celldex Therapeutics Inc.
31.69%
547,707
$20,270,636,000 1.28%
Roivant Sciences Ltd
86.52%
1,868,412
$19,749,115,000 1.24%
Establishment Labs Holdings Inc
204.08%
429,244
$19,504,847,000 1.23%
Inozyme Pharma, Inc.
No change
4,280,308
$19,090,174,000 1.20%
Revolution Medicines Inc
Opened
455,099
$17,662,392,000 1.11%
Kura Oncology Inc
64.41%
825,243
$16,991,753,000 1.07%
Insmed Inc
Opened
227,747
$15,259,049,000 0.96%
Boston Scientific Corp.
51.65%
171,080
$13,174,871,000 0.83%
Madrigal Pharmaceuticals Inc
133.42%
44,417
$12,443,867,000 0.78%
Insulet Corporation
72.31%
60,967
$12,303,141,000 0.78%
Shockwave Med Inc
Closed
35,000
$11,397,050,000
Pharvaris N V
2.88%
601,534
$11,308,839,000 0.71%
Axonics Inc
0.74%
150,490
$10,117,443,000 0.64%
Immatics N.v
63.18%
796,704
$9,257,700,000 0.58%
Cabaletta Bio Inc
183.98%
1,220,400
$9,128,592,000 0.58%
Pepgen Inc
11.42%
561,128
$8,955,603,000 0.56%
Edgewise Therapeutics Inc
Opened
475,691
$8,567,195,000 0.54%
Immunome, Inc.
10.31%
655,680
$7,933,728,000 0.50%
Exact Sciences Corp.
20.77%
181,828
$7,682,233,000 0.48%
Inari Med Inc
1,425.43%
155,838
$7,503,600,000 0.47%
Dexcom Inc
Opened
61,494
$6,972,190,000 0.44%
Inhibrx Biosciences Inc
Opened
463,315
$6,565,174,000 0.41%
Achieve Life Sciences Inc.
8.55%
1,388,372
$6,525,348,000 0.41%
Waters Corp.
Opened
21,804
$6,325,776,000 0.40%
Aerovate Therapeutics Inc
No change
3,758,686
$6,239,419,000 0.39%
4D Molecular Therapeutics Inc.
36.82%
271,155
$5,691,543,000 0.36%
Marinus Pharmaceuticals Inc
196.32%
4,151,576
$4,857,344,000 0.31%
Nextcure Inc
No change
2,671,856
$4,248,251,000 0.27%
Erasca Inc
Opened
1,699,528
$4,010,886,000 0.25%
Phibro Animal Health Corp.
Opened
237,009
$3,974,641,000 0.25%
Baxter International Inc.
488.84%
117,769
$3,939,373,000 0.25%
Fusion Pharmaceuticals Inc.
Closed
157,172
$3,350,907,000
Avantor, Inc.
39.32%
141,045
$2,990,154,000 0.19%
Teleflex Incorporated
12.41%
13,649
$2,870,794,000 0.18%
Masimo Corp
0.80%
20,161
$2,539,076,000 0.16%
Cooper Cos Inc
Closed
21,236
$2,154,605,000
Bolt Biotherapeutics Inc
No change
2,754,437
$2,065,828,000 0.13%
Inspire Med Sys Inc
23.47%
10,000
$1,338,300,000 0.08%
Disc Medicine Inc
373.93%
29,256
$1,318,568,000 0.08%
Perspective Therapeutics Inc
Opened
132,089
$1,316,927,000 0.08%
Zimmer Biomet Holdings Inc
Opened
10,630
$1,153,674,000 0.07%
LivaNova PLC
0.71%
20,602
$1,129,402,000 0.07%
Immatics N.v
Opened
348,731
$932,855,000 0.06%
NuCana plc
Closed
4,708,614
$1,224,240,000
Avidity Biosciences, Inc.
Opened
21,425
$875,211,000 0.06%
Ikena Oncology Inc
No change
382,616
$631,316,000 0.04%
Amylyx Pharmaceuticals Inc
2.29%
299,691
$569,413,000 0.04%
Astria Therapeutics Inc
Opened
60,692
$552,297,000 0.03%
Perspective Therapeutics Inc
Closed
430,105
$511,825,000
PDS Biotechnology Corporation
No change
142,635
$417,921,000 0.03%
Pulmonx Corp
Opened
60,246
$381,960,000 0.02%
Kyverna Therapeutics Inc
378.50%
47,850
$358,875,000 0.02%
Structure Therapeutics Inc
2.08%
8,915
$350,092,000 0.02%
Mirum Pharmaceuticals Inc
Closed
3,012
$75,661,000
No transactions found
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